Liverpool will also aim to return to the last 16 after nine year hiatus

Napoli will aim to make it to the knockouts for only the third time when the final Champions League matches of the last four groups — E, F, G, & H — are played on Wednesday.

With Manchester City already assured of top spot, Shakhtar Donetsk and Serie A high-flyer Napoli are fighting it out for second in Group F.

Shakhtar takes on City in Ukraine and will qualify for the knockout rounds if it can end Pep Guardiola’s side’s 20-match winning streak.

Napoli heads to pointless Feyenoord knowing that victory would see it snatch a ticket for the last 16 if Shakhtar loses to City, after its 3-0 victory over the Ukrainians last time out gave it the better head-to-head record.

Napoli, which lost its unbeaten start to the Italian season with a 1-0 defeat by Juventus on Friday, is looking to reach the last 16 for only the third time.

Also seeking a return to the last-16 will be five-time champion Liverpool, when it welcomes Spartak Moscow to Anfield knowing that it only needs to avoid defeat to progress for the first time in nine years.

Victory would also wrap up top spot in Group E. Jurgen Klopp’s men should have secured qualification a fortnight ago, but blew a three-goal lead to draw 3-3 at Sevilla.

The Reds are bidding to banish the memories of three years ago when a 1-1 home draw with Basel sent them packing.

Russian champion Spartak has to win to have any chance of progressing. Sevilla only needs to draw with Maribor in Slovenia to qualify for the knockout stage, and would go through as group winners if it wins and Liverpool slips up.

In Group G, Besiktas is through as the topper with 11 points. The fight is for the second spot, with both Porto and RB Leipzig level on seven points; the former has a better goal difference of two.

Porto is through if it wins, or as long as it is at least level on points with Leipzig due to superior head-to-head (on goal difference).

Leipzig must pick up more points than Porto to finish second.

While Leipzig will welcome Besiktas, Porto will plays host to last year’s semifinalist and this year’s bottom placed team Monaco.

Tottenham has qualified as Group H winner due to its superior head-to-head over Real Madrid, which too has qualified as group runner-up.

Dortmund and APOEL will contest for third place. In case both teams draw Dortmund will qualify due to superior goal difference in all matches. In case both teams win or lose the final ranking will depend on the number of goals scored and conceded in the last two matches.